The YOSEMITE/RHINE (NCT03622580/NCT03622593) trials were double-masked, active comparator–controlled, phase 3 trials investigating the efficacy, safety, and durability of faricimab 6.0 mg versus aflibercept 2.0 mg in patients with diabetic macular edema (DME). It was a pleasure to speak with Dr Andreas Pollreisz (Medical University of Vienna, Austria) around the YOSEMITE/RHINE trials as well as their […]

The RESTORE trial (NCT04945772) is a phase 2b randomized, sham-controlled, multi-centre, multi-dose, double-masked clinical trial evaluating the efficacy and safety of MCO-010 optogenetic therapy in adults with retinitis pigmentosa. MCO-010 is an ambient-light activatable Multi-Characteristic Opsin (MCO) optogenetic therapy for vision restoration. It was a pleasure to speak with Prof. David Boyer (Retina Vitreous Associates Medical […]

Faricimab inhibits both angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF)-A pathways which may extend treatment durability beyond current anti-VEGF therapies for diabetic macular edema (DME). It was a pleasure to speak with Dr Jennifer Lim (University of Illinois Chicago, IL, USA) around the treat-and-extend regimen with faricimab in the YOSEMITE/RHINE (NCT03622580/NCT03622593) trials and the […]

The CANDELA trial (NCT04126317) was a phase II, randomized, single-masked, open-label, clinical trial that assessed the safety and efficacy of aflibercept 8 mg versus the standard dose of 2 mg in patients with neovascular age-related macular degeneration (nAMD). It was a pleasure to speak with Dr Jordana Fein (Retina Group of Washington Fairfax, VA, USA) […]

Dry eye disease (DED) is a multifactorial condition of the ocular surface and tears. It is frequently encountered in ocular practices, comprising nearly 33% of visits in the USA, and with an estimated global prevalence ranging between 5% and 50%.1,2 The chronic symptoms and discomfort reported by patients with DED directly impact their quality of life […]

The treatment options for neurotrophic keratitis (NK) are ever-evolving as the pathogenesis of this increasingly prevalent degenerative keratopathy is further elucidated. Currently available therapeutics can be divided into medical, procedural and surgical interventions that directly address the effects of corneal denervation as well as the comorbid conditions causing superimposed infection and inflammation in the affected […]

The challenge of patient adherence Patient adherence is a major concern in the field of glaucoma, where medication adherence rates can be as low as 40–55% due to complex dosing regimens, unpleasant side effects and difficulty with eyedrop administration.1,2 Moreover, 25% of patients with glaucoma do not refill their second eyedrop prescription, making it challenging for […]

Glaucoma is a major cause of irreversible blindness worldwide.1,2 High intraocular pressure (IOP) is one of the major risk factors for the development and progression of open-angle glaucoma (OAG) but is not an essential criterion for diagnosis.3,4 Nonetheless, lowering the IOP is considered the only proven intervention to decelerate disease progression.3–5 IOP can be reduced using topical hypotensive […]