An Introduction to Neuro-ophthalmology
Neuro-ophthalmology is a challenging area that incorporates many conditions that affect the neurological control of the visual system, such as strabismus and optic neuritis. Management often requires a multidisciplinary approach involving ophthalmology and neurology specialists.
Browse the content below, to see leading experts discuss the latest data in video interviews and short articles from our conference hub. You can also view the selection of peer-reviewed articles from our journals. If you’re looking to learn more about the impact of these developments on patient outcomes, our educational activities are a great resource.
Pharmacologic Mydriasis and Cycloplegia: A Review of Novel Delivery Devices
touchREVIEWS in Ophthalmology. 2023;17(2):1–3:Online ahead of journal publication
Mydriasis physiology Mydriasis refers to physiologic or pharmacologic pupillary dilation. Physiologic pupillary dilation occurs naturally as a response to low light and viewing objects in the distance. This process is mediated by both the iris sphincter and the iris dilator muscles, the latter of which contracts in response to sympathetic stimulation and relaxes in response to […]
The complement system in NMOSD and MG: A target for therapeutic benefit?
Watch specialists in neurological disorders share their insights on the role of complement and complement therapeutics in patients with neuromyelitis optica spectrum disorder (NMOSD) and myasthenia gravis (MG).
- Describe the role of complement in the pathophysiology of NMOSD and MG
- Evaluate markers of complement activation as diagnostic and prognostic biomarkers in NMOSD and MG
- Discuss recently approved and experimental inhibitors of the complement system for the treatment of NMOSD and MG
Latest developments in neuromyelitis optica spectrum disorder: Diagnostics, treatments and patient-centred care
Three experts examine evidence-based approaches for early and accurate diagnosis, appropriate treatment selection and patient-centred care to mitigate the clinical burden of neuromyelitis optica spectrum disorder.
- Recall strategies that facilitate an early and accurate diagnosis of NMOSD
- Describe how evidence from clinical trials investigating current and emerging treatments for NMOSD informs clinical decision making
- Select individualized management plans for patients with NMOSD to reduce the patient-reported burden of symptoms
Current and Emerging Therapies for Leber Hereditary Optic Neuropathy
touchREVIEWS in Ophthalmology. 2023;17(1):21–24 DOI: https://doi.org/10.17925/USOR.2023.17.1.21
Leber hereditary optic neuropathy (LHON) is a mitochondrially inherited optic nerve disease characterized by bilateral (sequential or simultaneous), subacute, painless central vision loss.1 LHON was first described in 1871 by the German ophthalmologist Theodor Leber.2 However, it was not until 1988 that the mitochondrial mutation was discovered by Wallace et al.3 LHON is the most common hereditary mitochondrial optic neuropathy. Several primary mitochondrial […]
Mark Moster: RESCUE, REVERSE and RESTORE clinical trials: Investigating gene therapy for Leber’s hereditary optic neuropathy
Leber’s hereditary optic neuropathy (LHON) is characterized by bilateral, painless subacute loss of central vision during young adult life. We were delighted to speak with Prof. Mark Moster (Wills Eye Hospital, Philadelphia, PA, USA) to discuss the findings in the RESCUE, REVERSE and RESTORE clinical trials. Questions: Could you give us a brief overview of […]
Considering the complete picture in neuromyelitis optica spectrum disorder: Optimizing diagnosis and management to improve patient outcomes
Watch three leading experts discuss diagnosis, treatment and care provision for patients with neuromyelitis optica spectrum disorder (NMOSD), with updates on the latest data for immunotherapy treatment options and guidance on how to support the holistic management of patients through multidisciplinary teams.
- Describe the clinical manifestations of neuromyelitis optica spectrum disorder (NMOSD), the typical MRI findings and differential diagnoses
- Analyse the treatment options for the prevention of NMOSD attacks and their selection criteria
- Determine strategies for the holistic management of the broad range of symptoms experienced by patients with NMOSD
Ben Thompson, ARVO 2021: Latest Studies on Interventions for Visual Cortex Neuroplasticity
It was a pleasure to catch up with Ben Thompson (University of Waterloo, Waterloo, ON, Canada), to discuss the latest clinical data on interventions for the enhancement of visual cortex neuroplasticity. Questions What interventions enhancing visual cortex neuroplasticity are currently being investigated in humans with amblyopia? (00:15) Could you give us a brief overview of […]
Ben Thompson, ARVO 2021: Enhancement of Visual Cortex Neuroplasticity in Adults with Amblyopia
We spoke with Ben Thompson (University of Waterloo, Waterloo, ON, Canada) about neuroplasticity, and the relevance of visual plasticity in the treatment of amblyopia. Questions Could you give us a brief overview of neuroplasticity and its biological basis? (00:13) What manifestations of visual plasticity exist in the visual cortex of adults? (01:11) What is the […]
Nonorganic Vision Loss
European Ophthalmic Review. 2020;14(1):26–33 DOI: https://doi.org/10.17925/EOR.2020.14.1.26
Nonorganic vision loss (NOVL) or functional vision loss (FVL) is the presence of abnormal vision, or visual fields, without an organic pathology, despite a thorough and comprehensive evaluation. The symptoms will be inconsistent with the results of an objective examination.1–3 In some cases, vision loss is intentionally feigned, while in others it occurs under unconscious conditions. […]
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