An Introduction to Neuro-ophthalmology
Neuro-ophthalmology is a challenging area that incorporates many conditions that affect the neurological control of the visual system, such as strabismus and optic neuritis. Management often requires a multidisciplinary approach involving ophthalmology and neurology specialists.
Browse the content below, to see leading experts discuss the latest data in video interviews and short articles from our conference hub. You can also view the selection of peer-reviewed articles from our journals. If you’re looking to learn more about the impact of these developments on patient outcomes, our educational activities are a great resource.
Current and Emerging Therapies for Leber Hereditary Optic Neuropathy
touchREVIEWS in Ophthalmology. 2023;17(1):21–24
Leber hereditary optic neuropathy (LHON) is a mitochondrially inherited optic nerve disease characterized by bilateral (sequential or simultaneous), subacute, painless central vision loss.1 LHON was first described in 1871 by the German ophthalmologist Theodor Leber.2 However, it was not until 1988 that the mitochondrial mutation was discovered by Wallace et al.3 LHON is the most common hereditary mitochondrial optic neuropathy. Several primary mitochondrial […]
Mark Moster: RESCUE, REVERSE and RESTORE clinical trials: Investigating gene therapy for Leber’s hereditary optic neuropathy
Leber’s hereditary optic neuropathy (LHON) is characterized by bilateral, painless subacute loss of central vision during young adult life. We were delighted to speak with Prof. Mark Moster (Wills Eye Hospital, Philadelphia, PA, USA) to discuss the findings in the RESCUE, REVERSE and RESTORE clinical trials. Questions: Could you give us a brief overview of […]
Considering the complete picture in neuromyelitis optica spectrum disorder: Optimizing diagnosis and management to improve patient outcomes
Watch three leading experts discuss diagnosis, treatment and care provision for patients with neuromyelitis optica spectrum disorder (NMOSD), with updates on the latest data for immunotherapy treatment options and guidance on how to support the holistic management of patients through multidisciplinary teams.
- Describe the clinical manifestations of neuromyelitis optica spectrum disorder (NMOSD), the typical MRI findings and differential diagnoses
- Analyse the treatment options for the prevention of NMOSD attacks and their selection criteria
- Determine strategies for the holistic management of the broad range of symptoms experienced by patients with NMOSD
Ben Thompson, ARVO 2021: Latest Studies on Interventions for Visual Cortex Neuroplasticity
It was a pleasure to catch up with Ben Thompson (University of Waterloo, Waterloo, ON, Canada), to discuss the latest clinical data on interventions for the enhancement of visual cortex neuroplasticity. Questions What interventions enhancing visual cortex neuroplasticity are currently being investigated in humans with amblyopia? (00:15) Could you give us a brief overview of […]
Ben Thompson, ARVO 2021: Enhancement of Visual Cortex Neuroplasticity in Adults with Amblyopia
We spoke with Ben Thompson (University of Waterloo, Waterloo, ON, Canada) about neuroplasticity, and the relevance of visual plasticity in the treatment of amblyopia. Questions Could you give us a brief overview of neuroplasticity and its biological basis? (00:13) What manifestations of visual plasticity exist in the visual cortex of adults? (01:11) What is the […]
Nonorganic Vision Loss
European Ophthalmic Review. 2020;14(1):26–33 DOI: https://doi.org/10.17925/EOR.2020.14.1.26
Nonorganic vision loss (NOVL) or functional vision loss (FVL) is the presence of abnormal vision, or visual fields, without an organic pathology, despite a thorough and comprehensive evaluation. The symptoms will be inconsistent with the results of an objective examination.1–3 In some cases, vision loss is intentionally feigned, while in others it occurs under unconscious conditions. […]
Neuro-ophthalmology in the Geriatric Eye
US Ophthalmic Review. 2020;13(1):30–3 DOI: https://doi.org/10.17925/USOR.2020.13.1.30
As the percentage of elderly people that make up the population of the USA grows, it is imperative to shift our focus on how to best address their needs and outline an approach to the geriatric eye. This review describes common physiologic and pathologic conditions affecting the aging eye including presbyopia, posterior cortical atrophy, giant […]
A Review of Binocular Treatment for Amblyopia
European Ophthalmic Review. 2020;14(1):34–8 DOI: https://doi.org/10.17925/EOR.2020.14.1.34
The term amblyopia, derived from the Greek words α’µβλυ’ς (weak) and ω˛″ψ (eye), is defined as a unilateral (or, less commonly, bilateral) reduction of visual acuity as a result of inadequate visual experience during early life, which leads to a disruption of the normal visual neurodevelopment process.1 It is associated with anisometropia, ametropia, stimulus deprivation, strabismus and nystagmus, and it […]
True and False Localization in Neuro-ophthalmology—a Report of Two Cases
US Ophthalmic Review, 2019;12(2):98–102
The Parkinson sign is classically described as a sixth nerve palsy and an ipsilateral Horner syndrome that localizes to the cavernous sinus. 1,2 The localizing value of any afferent and efferent (e.g., Horner syndrome) pupillary finding with an ipsilateral ocular motor cranial neuropathy merits revisiting the Parkinson sign.3,4 For example, a unilateral pupil-sparing cranial nerve III palsy with […]
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