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Management Options in Pediatric Cataract

Published Online: March 15th 2012 US Ophthalmic Review, 2012;5(1):44–7 DOI: http://doi.org/10.17925/USOR.2012.05.01.44
Authors: Abhay R Vasavada, Sajani K Shah, Vaishali Vasavada
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Abstract:
Overview

Pediatric cataract surgery remains a very important and difficult problem to manage and involves a team effort, the most important members of which are parents. While dramatic advances have occurred in this field during the past 10 years, some technical aspects of surgery, changing refraction, and functional outcome continue to pose significant problems. Manual capsulorhexis remains the gold standard for a successful outcome of pediatric cataract surgery as well as in deciding intraocular lens (IOL) placement. Primary management of the posterior capsule with or without anterior vitrectomy is mandatory depending on age of the child at surgery. Primary implantation of the IOL after cataract removal is gaining popularity, even for infants and young children. Predicting axial growth and the refractive change that accompanies it is one of the major challenges for the long-term care of children after surgery. The evaluation of rate of axial growth and its correlation with age at surgery, laterality, aphakia/pseudophakia, and visual axis obscuration is a positive step in this direction. Finally, appropriate visual rehabilitation and amblyopia therapy are the cornerstones for the child’s final visual development.

Keywords

Pediatric cataract surgery, congenital cataract, posterior capsule, visual axis opacification, anterior vitrectomy, visual rehabilitation

Article:

Over the past decade, advances in technology and refinements in surgical techniques have brought pediatric cataract surgery into the modern age. Automation and the use of intraocular lenses (IOLs) have facilitated better anatomical and functional outcomes. At one point, lensectomy was the standard treatment used in such cases. However, in recent times, small incisions, anterior capsulorhexis, bimanual irrigation/aspiration, and primary posterior capsulectomy and vitrectomy have become acceptable treatment options for infantile cataract. IOL implantation has become the standard of care for the optical rehabilitation of children with cataract, from the toddler age group and up.
Pediatric cataract surgery is a complex issue best left to surgeons familiar with its long-term complications and lengthy follow-up. Treatment is often difficult and tedious and requires a dedicated team effort, the most important of which are parents.

Indications for Surgery

Visually significant cataract in children calls for prompt surgical intervention to clear the ocular media and provide a focused retinal image. The timing of treatment is crucial to the visual development and successful rehabilitation of children, especially during early infancy. In cases of a unilateral dense cataract diagnosed at birth, the surgeon can wait until the patient is four to six weeks of age.1 In the case of bilateral cataract diagnosed at birth, a good visual outcome can be achieved if the child is operated before 10 weeks of age.2 It is important to keep the time interval between the surgeries performed on the two eyes to a minimum.

Pre-operative Evaluation

The importance of counseling parents cannot be overstressed. Parents should understand that treatment of the child starts only after surgery. They need to come for regular follow-up visits, see that the child wears glasses or contact lenses (CLs) despite the IOL implantation, and realize that the child may need occlusion therapy following surgery.
The pre-operative examination includes age-appropriate vision testing and details of strabismus and nystagmus. Visual function in older children can be assessed with charts, such as preferential looking charts (Teller acuity card, Keeler), Lea gratings and symbols (Precision vision, Lasalle), Sheridian Gardiner tests, and ‘E’ charts or Snellen’s charts. In very young children, who cannot co-operate for vision tests, the ability to fixate or follow light or objects should be assessed. The presence of squint or nystagmus should be recorded. A pre-operative examination with fully dilated pupils, if necessary under anesthesia, is mandatory in both the eyes prior to surgery. It includes examination under the operating microscope or slit-lamp biomicroscope to assess the type of cataract and intraocular pressure to rule out any association of glaucoma. The examination should also include measurement of the corneal diameter, posterior segment evaluation, keratometry, biometry, gonioscopy, and ultrasound biomicroscopy.
Clinical examination of the child should include a complete examination of all systems, including respiratory, nervous, and cardiovascular systems. Supportive laboratory investigations should include hemogram, blood sugar, titers for antibodies to TORCH agents (toxoplasmosis, other infections, rubella, cytomegalovirus, and herpes simplex virus), HIV, hepatitis B surface antigen, and X-rays, and echocardiography if required. Special tests to rule out metabolic diseases should be ordered whenever necessary.

Surgical Technique
Anterior Capsule Management

Anterior capsulorhexis is the anchor for pediatric cataract management, as it determines the surgical strategy and site of IOL fixation. The anterior capsule in children is very elastic, and therefore it may be difficult to perform a controlled manual continuous curvilinear capsulorhexis (CCC). However, it remains a gold standard for resistance to tearing and should be accomplished whenever possible. Difficulties in performing manual CCC in the infantile eye led researchers and surgeons to search for alternative methods to open the anterior capsule in children. Alternatives to manual CCC currently available include vitrectorhexis, radiofrequency diathermy with a Fugo plasma blade, the two-incision push–pull technique, and the four-incision technique.3–6 Wilson et al. analyzed pediatric anterior capsulotomy techniques in the porcine model and found that manual capsulorhexis produced the most extensible capsulotomy with the most regular and stable edge.7 In eyes with poor anterior capsule visibility, trypan blue (0.0125 %) was used to stain the anterior capsule. The shape, size, and edge integrity of anterior capsulotomy are very important for the long-term centration of the IOL (Figure 1).

Management of the Posterior Capsule and Anterior Vitreous Face

The most frequent and significant problem following pediatric cataract surgery is visual axis opacification (VAO).8–13 (Figure 2). Maintenance of a clear visual axis remains a high priority when planning management of the posterior capsule in the amblyogenic age range. An important question that remains is when should the posterior capsule be left intact? Primary posterior capsulectomy (with or without anterior vitrectomy) are considered ‘routine surgical steps,’ especially in young children.14–20 Posterior capsulotomy can be performed using various approaches, including manual posterior continuous curvilinear capsulorhexis (PCCC), vitrectorhexis, radiofrequency diathermy, and the Fugo plasma blade.21,22 Manual PCCC is performed before IOL implantation, whereas, if a pars plana vitrectorhexis is performed, it is done after the IOL is implanted.23,24 The size of the posterior capsulorhexis should be large enough to provide a clear central visual axis, but smaller than the IOL optic, so as to allow stable in-the-bag IOL fixation. Manual PCCC offers the advantage of a controlled size and strong edges, but is more difficult to perform (Figure 3).
A potential complication associated with this procedure is disruption of the anterior vitreous face (AVF).25 The signs of AVF disruption vary from subtle to obvious, and include:

  • the presence of vitreous strands in the anterior chamber;
  • the attachment of the vitreous to the capsular flap; and
  • distortion of the capsulorhexis margin.

Recently, we described a technique to render the vitreous visible to the anterior segment surgeon. On completion of the PCCC, 0.1 ml of a suspension of preservative free triamcinolone acetonide (Aurocort) was injected for visualizing the AVF as well as the presence and extent of vitreous in the anterior chamber.26,27 After vitrectomy, if the surgeon has not cleared the residual vitreous strands triamcinolone can now be used second time to identify clearly the superficial vitreous gel, which may have otherwise gone unnoticed. After IOL implantation and removal of the residual ophthalmic viscosurgical device, the surgeon again injects 0.1 ml of the suspension into the anterior chamber. Additional anterior vitrectomy is performed if vitreous strands are identified in the anterior chamber.

Intraocular Lens Implantation

One of the most important pre-operative considerations is whether to implant an IOL or not. Surgeons should be prepared for the common question “Would you implant an IOL if this were your child?” The capability of the IOL to offer constant visual input is an important advantage for a better visual outcome after pediatric cataract surgery. Use of IOL provides at least a partial optical correction at all times. As a consequence of the advantage it offers, primary IOL implantation has slowly gained acceptance for the management of childhood cataracts. However, as of 2007, use of IOL remains controversial for the management of infantile cataract. The important concerns about primary IOL implantation during infancy are the technical difficulties of implanting an IOL and selecting an IOL power, and the higher rate of VAO.28–37 At present, only adult-sized IOLs are available, which are often difficult to implant in infantile eyes and may cause complications in the long run.
The size of the posterior capsulorhexis should be large enough to provide a clear central visual axis, but smaller than the IOL optic so as to allow stable in-the-bag IOL fixation. Even if the surgeon is not planning to implant an IOL in a specific eye, it is important to leave behind sufficient anterior and posterior capsular support at the time of cataract surgery to facilitate subsequent IOL implantation. The common practice is to perform posterior capsulectomy and anterior vitrectomy before IOL implantation if the limbal approach is used, whereas if a pars plana vitrectorhexis is performed, it is done after the IOL is implanted. Furthermore, there is no agreement as to whether the IOL should be implanted before or after the primary posterior capsulectomy. Some surgeons perform a pars plicata capsulectomy and vitrectomy with the vitrectome after implanting the IOL in the bag. Both polymethyl methacrylate and hydrophobic acrylic foldable IOLs have been widely used in pediatric eyes. However, several studies show that hydrophobic acrylic IOLs are preferable as they offer better uveal biocompatibility and a decreased incidence of VAO, with hydrophobic acrylic IOLs causing a delayed onset of posterior capsule opacification (PCO).38–42 For bilateral cataract during the first year, aphakic glasses and/or CL use may be a reasonable option; however, for unilateral cataract, we are truly equipoised between whether or not to offer primary IOL implantation at the time of infantile cataract surgery. A large randomized clinical trial – the Infant Aphakia Treatment Study is currently underway to compare primary IOL implantation to CL correction in children undergoing unilateral cataract surgery in the first six months of life.

Secondary Intraocular Lens Implantation

Eyes that are left aphakic are likely to require a secondary IOL implantation. Even if the surgeon is not planning to implant an IOL primarily, it is important to leave behind sufficient anterior and posterior capsular support at the time of cataract surgery to facilitate in-the-bag or sulcus-fixated IOL implantation to allow ciliary sulcus or in-the-bag placement of an IOL once the child and eye grow.

Newer Approaches
Optic Capture

An alternative technique to stabilize the IOL was introduced with the concept of capturing an IOL optic through anterior capsulorhexis. The haptics were placed in the ciliary sulcus and the IOL optic was then placed through the anterior capsulorhexis to ‘capture’ the IOL for stable optic fixation. This concept has been used to develop the technique of posterior capsulorhexis with optic capture through posterior capsulorhexis (haptics in the bag) to prevent PCO.43–51
Conventional or posterior optic capture can be achieved by capturing the optic through anterior capsulorhexis (haptics in the ciliary sulcus, optic in the bag), both the rhexes (haptics in the ciliary sulcus, optic behind the posterior capsule), and posterior capsulorhexis (hepatics in the bag, optic behind the posterior capsule). The third concept is also known as optic buttonholing. The posterior capsule lies on top of the IOL optic and the LECs, which are deviated anteriorly, no longer have access to the retrolenticular space. The optic–haptic junction is the only place in which there is no opposition between the leaflets of the anterior and posterior capsules (Figure 4).

Sealed Capsule Irrigation

Maloof and co-workers designed a sealed capsule irrigation device (Perfect CapsuleTM) that can help to irrigate the capsular bag selectively, which may help pediatric cataract surgeons to eliminate or delay VAO by using irrigation chemicals through this device.52–55

Manual Posterior Continuous Curvilinear Capsulorhexis via Pars Plana Approach

Vasavada and co-workers recently introduced a technique of performing manual PCCC via the pars plicata.56 After implantation of the IOL in the capsular bag all the incisions are sutured with 10-0 nylon and residual Provisc is left in the anterior chamber. The pars plicata entry is made 1–1.5 mm behind the limbus and an initial puncture is made in the center of the posterior capsule and later a coaxial capsulorhexis forceps is introduced and a flap generated. The edge of the flap is grasped and then re-grasped every two clock hours, fashioning the PCCC in a clockwise manner.

Bag-in-the-lens Implantation

Tassignon and colleagues reported the outcome of a surgical procedure in pediatric cataractous eyes that they called ‘bag-in-the-lens’.57,58 In this technique, the anterior and posterior capsules are placed in the groove of a specially designed IOL after a capsulorhexis of the same size is created in both capsules The principle behind this IOL design is to ensure a clear visual axis by mechanically tucking the two capsules into the IOL, and thereby prevent any migration of proliferating lens epithelial cells.

Sutureless Vitrectomy

The 25 as well as 23 gauge high-speed vitrectomes have found a growing number of applications in pediatric surgery via a pars plana approach or transcorneal approach.59,60 In a clinical series, it was found that the 25-gauge system offers several advantages when used in infantile cataract extraction. By using this system, the surgical wounds are rendered safe and secure. Moreover, when created with a flat paracentesis knife, the incisions do not need to be closed. The authors suggested that the 25-gauge vitrectomy system appears ideally suited for the management of congenital cataract in children younger than one year.59,60

Heparin in Irrigating Solution

Heparin has been used in intraocular irrigating solutions to reduce inflammatory reactions after pediatric cataract surgery. It has been documented that infusion of enoxaparin, a low molecular weight heparin, during pediatric cataract surgery may minimize the post-operative inflammatory response.61

Summary

While dramatic advances have occurred in this field over the past 10 years, some technical aspects of surgery, changing refraction, and functional outcome continue to pose significant problems. Primary management of the posterior capsule is mandatory depending on the age of the child at surgery. With refinements in surgical techniques, improvisation of IOLs, and better understanding of growth of the pediatric eye, in the coming years IOL implantation is likely to become an established mode of treatment of children, even in the youngest age group. ■

Article Information:
Disclosure

The authors have no conflicts of interest to declare.

Correspondence

Abhay R Vasavada, MS, FRCS, Iladevi Cataract & IOL Research Center, Raghudeep Eye Clinic, Gurukul Road, Memnagar, Ahmedabad 380052, India. E: icirc@abhayvasavada.com

Received

2011-10-01T00:00:00

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