Ocular Immunology and Inflammation
An Introduction to Uveitis and Ocular Immunology
Uveitis is a leading cause of irreversible blindness in the developed world. First-line treatment involves corticosteroids followed by immunosuppressant therapy and an anti-tumour necrosis factor-alpha (TNF-α agent). Further investigation into new immunotherapies targeting different immune components is promising for the future.
Browse the content below, to see leading experts discuss the latest data in video interviews and short articles from our conference hub. You can also view the selection of peer-reviewed articles from our journals. If you’re looking to learn more about the impact of these developments on patient outcomes, our educational activities are a great resource.
Ocular Immunology and Inflammation Content
Immunosuppressive Therapy in Giant Cell Arteritis: Do Steroids Still Reign Supreme?
touchREVIEWS in Ophthalmology. 2022;16(2):85–91 DOI: https://doi.org/10.17925/USOR.2022.16.2.85
Giant cell arteritis (GCA) is a medium-to-large vessel vasculitis that affects branches of the thoracic aorta, including the carotid artery.1–4 The most feared ophthalmic complication is blindness (seen in up to ~25% of cases) due to arteritic ischaemic optic neuropathy involving ophthalmic artery circulation (e.g. retinal, choroidal or optic nerve). GCA may also lead to serious […]
Carlos Pavesio, EURETINA 2021: Fluocinolone Acetonide Insert – A Study
We were delighted to catch up with Carlos Pavesio (Moorfields Eye Hospital, London, UK), who shared details of his study to evaluate the safety and efficacy of the fluocinolone acetonide insert for the treatment of noninfectious uveitis. Questions: What were the aims and design of your recent study? (00:31) What were the efficacy and safety […]
Carlos Pavesio, EURETINA 2021: Fluocinolone Acetonide Insert for Noninfectious Uveitis
It was great to speak with Carlos Pavesio (Moorfields Eye Hospital, London, UK) about unmet needs in treatment of noninfectious uveitis, and the clinical evidence supporting the efficacy of the fluocinolone acetonide insert. Questions: What are the unmet needs in the treatment of noninfectious uveitis? (00:33) Could you tell us a little about the […]
Evaluation of Proptosis: A Primer
touchREVIEWS in Ophthalmology. 2021;15(1):26–32 DOI: https://doi.org/10.17925/OPHT.2021.15.1.26
An abnormal protrusion of the eyeball, beyond the boundaries of the bony orbit, is termed ‘proptosis’. A similar appearance, seen in endocrine dysfunction, especially thyroid disorders, is called ‘exophthalmos’. These conditions are frequently encountered in clinical practice, and for students, residents and trainees, the situation may prove rather challenging. This primer presents a concise blueprint […]
Yasha Modi, Hawaiian Eye and Retina 2021: Infectious Uveitis – Diagnosis and Management
It was a pleasure to speak with Yasha Modi (NYU Langone, NY, USA) about his presentation at Hawaiian Eye and Retina 2021 on diagnosis and management of infectious uveitis. Questions What clinical clues can help the diagnostic process in infectious uveitis? (00:24) How do you work up infectious uveitis and how do you initiate a […]
Yasha Modi, Hawaiian Eye and Retina 2021: Infectious Uveitis – Aetiologies, Presentation and Diagnosis
It was a pleasure to speak with Yasha Modi (NYU Langone, NY, USA) about his presentation at Hawaiian Eye and Retina 2021 on diagnosis and management of infectious uveitis. Question Could you give us a brief overview of the epidemiology, aetiologies and presentations of infectious uveitis? (00:25) What are the major challenges in the diagnosis […]
Suprachoroidal Injection of Triamcinolone— Review of a Novel Treatment for Macular Edema due to Noninfectious Uveitis
US Ophthalmic Review. 2020;13(2):76-9 DOI: https://doi.org/10.17925/USOR.2020.13.2.76
Uveitis consists of a wide array of inflammatory disorders of the uveal tract and surrounding structures, which may lead to irreversible ocular damage and lasting visual impairment if not appropriately treated in a timely manner. As the fifth most common cause of vision loss in the developed world, uveitis accounts for 3–10% of legal blindness […]
Bennie H Jeng, AAO 2020 – Management of Common Allergic and Immunologic Diseases of the Conjunctiva and Cornea
It was a pleasure to speak with our valued Editorial Board member, Bennie H Jeng (University of Maryland School of Medicine, Baltimore, MD, USA), who talked us through his AAO 2020 presentation on managing allergic and immunologic diseases of the conjunctiva and cornea, the impact of immunology on our understanding and treatment of allergic and […]
Monoclonal Antibodies in the Treatment of Orbital Inflammation
Orbital inflammation can result from a number of inflammatory conditions including dacryoadenitis, myositis, cellulitis, optic perineuritis, periscleritis, orbital apicitis, thyroid eye disease (TED), and a focal mass.1 It may present as acute, subacute, or chronic disease and has a wide range of clinical manifestations, most commonly pain and periorbital swelling.2 Historically, systemic corticosteroids have been […]
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