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Editorial Imaging 1 CNV is deduced by the presence of pooling within PED and/or the presence of hot spots. On the contrary, OCTA directly shows the vessels themselves, and allows the investigator to accurately diagnose and classify the NV complex. 2 Type 2 NV typically complicates high myopia and inflammatory retinopathies, but may also be present in AMD. Type 2 CNV discloses very typical OCTA patterns. NV membrane appears as either a medusa- shaped complex or a glomerulus-shaped lesion, typically located in the outer retina and CC layer. The medusa-shaped has well-defined oval shape, produced by a very dense high-flow network (highly active NV at presentation). The glomerulus-shaped lesion is a round, well defined and dense tangle of small new vessels. Both lesions may also be found on segmentation performed at the level of the CC. In the CC projection, the peripheral margins of the lesion display as a dark ring, and one or more central feeder vessels extending deeply in the choroidal layers are usually visible. The clinician may easily diagnosis type 2 NV using OCTA, especially in retinal areas where normally vessels are absent, as in the subretinal space. After long-term treatment, the NV lesion becomes fibrotic and its OCTA features change. 3 Type 3 NV appears as a retina-retinal anastomosis emerging from the DCP, originating a high-flow and tuft-shaped NV lesion. It could be segmented in the outer retinal layers, and in late-stage disease it finally crosses the subretinal RPE space. In the CC segmentation, a small clew- like lesion corresponds to the above-mentioned tuft-shaped network. In some cases, this glomerular lesion is connected with the choroid though a small-caliber vessel. 4 The CNV subtypes are usually classified using FA and/or ICGA (classic, prevalently classic, minimally classic, occult), but OCTA easily depicts the exact anatomy and the distribution of the vascular networks, both above and below the RPE. This aspect is of paramount importance, particularly in the case of mixed subtypes of CNVs. 5 Polypoidal choroidal vasculopathy (PCV) typically presents as hypo- flow round lesion on OCTA. Signal absence is not indicating blood flow lack, but rather that blood flow is not within the device detection 1. 2. 3. 30 Chalam KV, Sambhav K, Optical coherence tomography angiography in retinal diseases, J Ophthalmic Vis Res, 2016;11:84–92. Iafe NA, Phasukkijwatana N, Sarraf D, Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration, Dev Ophthalmol, 2016;56:45–51 Souied EH, El Ameen A, Semoun O, et al., Optical Coherence Tomography Angiography of Type 2 Neovascularization in Age-Related Macular Degeneration, Dev Ophthalmol, 2016;56:52–6. 4. 5. 6. 7. threshold. This could be due to either increased or decreased flow in the polyps and subsequent nonvisualisation of the vascular structure. It has been hypothesised that the apparent signal absence in PCV could be due either to the turbulent blood flow inside of the polyps, or to the fact that blood circulates only at the aneurism periphery. 6 Another critical aspect of this new imaging method is to describe the changes of both CNV natural history and after treatment. In early phases of presentation, NV appears as a tangled web of fine vessels, as a round tuft of small-caliber capillaries without dilated core feeder vessels. Chronic lesions demonstrate a distinctly different morphology, showing a highly organised vascular complex with vessels branching from a core trunk of multiple large, dilated feeder vessels. It has been proposed that these central trunks are more resistant to anti-VEGF treatment, since overlying pericytes protect their endothelial cells. Indeed, after each anti-VEGF injection a pruning of smaller vessels is immediately visible (after 24 hours), which intensify for 6–12 days. Reopening of new sprouting vessels is evident 20–50 days later, in case of CNV reactivation. Pruning the small peripheral branches seems to strengthen and increased the flow of the vascular trunk. This phenomenon, on OCTA, is known as ‘arterialisation’ of the main vascular trunk. 2,7 OCTA recently also raised interest in the scientific community on fibrosis and on low-activity (quiescent) CNVs. In almost all of fibrotic CNVs, a high-flow network was found inside the scar. Different vascular patterns have been also described (pruned vascular tree, tangled network, vascular loop). OCTA of subretinal fibrosis recently demonstrated a perfused and abnormal vascular network, as well as collateral architectural changes in the outer retina and in the CC. 8 One of the crucial aspects of assessing OCTA validity is to compare its diagnostic ability to gold standard techniques, such as FA and/or ICGA. One could also ask whether this new imaging method may replace in the future the traditional invasive methods of angiography. Actual studies report that OCTA specificity to detect CNV is 67.6%, and sensitivity is 86.5%. This data place now OCTA as a good strategy for diagnosis rather than for follow-up, but further studies are required to better assess the specific characteristics of CNV throughout treatment. 9 n Querques G, Miere A, Souied EH, Optical Coherence Tomography Angiography Features of Type 3 Neovascularization in Age-Related Macular Degeneration, Dev Ophthalmol, 2016;56:57–61 Liang MC, Witkin AJ, Optical Coherence Tomography Angiography of Mixed Neovascularizations in Age-Related Macular Degeneration, Dev Ophthalmol, 2016;56:62–70. Srour M, Querques G, Souied EH, Optical Coherence Tomography Angiography of Idiopathic Polypoidal Choroidal Vasculopathy, Dev Ophthalmol, 2016;56:71–6. Lumbroso B, Rispoli M, Savastano MC, et al., Optical 8. 9. Coherence Tomography Angiography Study of Choroidal Neovascularization Early Response after Treatment, Dev Ophthalmol, 2016;56:77–85. Souied EH, Miere A, Cohen SY, et al., Optical Coherence Tomography Angiography of Fibrosis in Age-Related Macular Degeneration, Dev Ophthalmol, 2016;56:86–90. Gong J, Yu S, Gong Y, et al., The Diagnostic Accuracy of Optical Coherence Tomography Angiography for Neovascular Age-Related Macular Degeneration: A Comparison with Fundus Fluorescein Angiography, J Ophthalmol, 2016;2016:7521478. EUR OP EAN OP H TH ALMIC RE VIE W