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Neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DME) are two leading causes of visual impairment and blindness in the USA.1,2 Faricimab is the first bispecific antibody approved by the US Food and Drug Administration in ophthalmology and was made available to retina specialists in January 2022 for treating nAMD and DME.3,4 The approval of faricimab gave retina […]

Retinal pharmacotherapy encompasses various drug delivery routes that offer potential avenues for effective treatment (Figure 1). Among these, intravitreal injections have emerged as the predominant method employed in clinical practice.1 They have established themselves as the primary approach for administering anti-vascular endothelial growth factor (anti-VEGF) therapy, serving as the frontline treatment for neovascular age-related macular degeneration […]

Welcome to the latest edition of touchREVIEWS in Ophthalmology. In this edition, we feature a range of reviews and editorials on various diseases, including glaucoma and ocular surface disease, to name but a few, discussing improvements in our understanding and novel treatment options for ophthalmological conditions. We begin this issue with an expert interview with […]

Faricimab inhibits both angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF)-A pathways which may extend treatment durability beyond current anti-VEGF therapies for diabetic macular edema (DME). It was a pleasure to speak with Dr Jennifer Lim (University of Illinois Chicago, IL, USA) around the treat-and-extend regimen with faricimab in the YOSEMITE/RHINE (NCT03622580/NCT03622593) trials and the […]

Diabetic macular edema is characterised by exudative fluid accumulation in the macula and is the most common form of sight-threatening retinopathy in people with diabetes affecting one in 15 people with diabetes. Intraocular pharmacotherapy with anti-VEGF agents is the standard of care. It was a pleasure to speak with Dr Jennifer Lim (University of Illinois […]

The CANDELA trial (NCT04126317) was a phase II, randomized, single-masked, open-label, clinical trial that assessed the safety and efficacy of aflibercept 8 mg versus the standard dose of 2 mg in patients with neovascular age-related macular degeneration (nAMD). It was a pleasure to speak with Dr Jordana Fein (Retina Group of Washington Fairfax, VA, USA) […]

Neovascular age-related macular degeneration (nAMD) is an advanced form of macular degeneration that historically has accounted for the majority of vision loss related to AMD. Current treatment consists of injecting inhibitors of vascular endothelial growth factor (VEGF) into the vitreous cavity to interfere with proliferation of choroidal neovascularization and to reduce vascular permeability. It was […]

The YOSEMITE/RHINE (NCT03622580/NCT03622593) trials were double-masked, active comparator–controlled, phase 3 trials investigating the efficacy, safety, and durability of faricimab 6.0 mg versus aflibercept 2.0 mg in patients with diabetic macular edema (DME). It was a pleasure to speak with Dr Andreas Pollreisz (Medical University of Vienna, Austria) around the YOSEMITE/RHINE trials as well as their […]