We are delighted to introduce the Fall edition of US Ophthalmic Review expertly introduced by Caroline Baumal. This edition features a variety of editorial, review, and research articles spanning the specialties of ophthalmology. In our opening editorial pieces Elizabeth Yeu shares her pearls for performing laser-assisted cataract surgery and John Berdahl explores the eye in space. Also in this edition, Robert Weinreb and colleagues review latanoprostene bunod for lowering intraocular pressure, and Bennie Jeng and Moulaye A Haidara discuss the early complications after penetrating keratoplasty. We hope you enjoy this edition of US Ophthalmic Review and that it provides a useful information relevant to your practice and interests.